Sweet syndrome DermNet

Neutrophilic dermatoses are autoinflammatory conditions often associated with systemic disease. Acute febrile neutrophilic dermatosis also has the eponymous name, Sweet syndrome or disease—named after Dr Robert Douglas Sweet from Plymouth, England, who first described it in 1964 Dermnet.com and the Dermnet Skin Disease Atlas are to be used only as a reference. Dermnet does not provide medical advice, diagnosis or treatment. Use of images for any purpose including but not limited to research, commercial, personal, or non-commercial use is prohibited without prior written consent Acute febrile neutrophilic dermatosis or Sweet disease presents acutely as a rash accompanied by systemic symptoms. The skin lesions are rapidly evolving juicy often 'pseudo- vesicular ' plaques or nodules accompanied by fever , leukocytosis , conjunctivitis and arthralgia

Acute febrile neutrophilic dermatosis DermNet N

Sweet syndrome was first described in the medical literature in 1964 by Dr. Robert Douglas Sweet. The disorder is classified as a neutrophilic dermatosis, which is a general term for a group of skin disorders characterized by the accumulation of neutrophils in the skin Acute febrile neutrophilic dermatosis, or Sweet syndrome, is a cutaneous eruption characterized clinically by the appearance of painful red plaques and nodules and histologically by an intense dermal neutrophilic infiltrate. Extracutaneous manifestations are rare Sweet syndrome is a very rare inflammatory skin condition characterized by a sudden onset of fever and painful rash on the arms, legs, trunk, face, or neck. It's also known as acute febrile neutrophilic dermatosis. In some cases, Sweet syndrome occurs with other medical conditions such as cancer, gastrointestinal infections, or pregnancy Sweet syndrome was first described by Dr. Robert Douglas Sweet in 1964, who documented the development of an acute inflammatory skin eruption with fever and leukocytosis in eight women, several of whom had preceding upper respiratory or gastrointestinal infections . Since then, Sweet syndrome has been observed in association with a broad range of disorders

Sweet's Syndrome. definition. Acute disease characterized by dark-red and slowly growing painful papules and plaques particularly on the face and the extremities accompanied by high fever and neutrophilic leukocytosis in the blood. The patients are usually women over 30 years of age Sweet's syndrome is an uncommon condition named after the English dermatologist, Dr Robert Sweet, who first described it in 1964. Sweet's syndrome usually presents with fever, a rise in white blood cells, raised red skin rashes and neutrophils (pus cells) infiltrating the upper layer of the skin. Fever and a rise in white blood cells are not always. Sweet's syndrome is a rare immunologically mediated condition that belongs to the group of neutrophilic dermatoses that must be differentiated particularly from Behcet's disease. It is characterized by red-brown plaques and nodules that are frequently painful and occur primarily on the head, neck, and upper extremities

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Neutrophilic dermatoses DermNet N

Acute febrile neutrophilic dermatosis is a skin condition characterized by fever, inflammation of the joints (arthritis), and painful skin lesions that appear mainly on the face, neck, back and arms. Although middle-aged women are most likely to develop this condition, it may also affect men, older adults and even infants Some people diagnosed with leukemia will develop Sweet's syndrome. A person with Sweet's syndrome will quickly develop a high fever and a rash. Typically, the rash consists of red or bluish lesions or tender bumps. The rash can occur anywhere, including the legs, arms, trunk, face, and neck. Sometimes, this rash also involves joint pain and can bring on symptoms of arthritis. Many things can cause Sweet's syndrome Erythema gyratum repens Necrolytic migratory erythema Sweet's syndrome Acquired ichthyosis Acanthosis nigricans Discuss and give feedback Skin disorders associated with malignancy External links DermNet NZ Ichthyosis DermNet NZ Pyoderma gangrenosum DermNet NZ Dermatomyositis DermNet NZ Acanthosis nigrican

Sweet syndrome, which is also associated with hematological malignancies, occurs with hyperleukocytosis, where NEH is associated with granulocytopenias occuring after chemotherapy administration. In addition, neutrophils are not limited to the dernis around eccrine coils and glands in Sweet syndrome, but found in the whole dermis Acute febrile neutrophilic dermatosis, also termed Sweet syndrome, is a reactive process characterized by the abrupt onset of tender, red-to-purple papules, and nodules that coalesce to form plaques. The plaques usually occur on the upper extremities, face, or neck and are typically accompanied by fever and peripheral neutrophilia Sweets Syndrome Toxic Epidermal Necrolysis Vasculitis: Dermnet.com and the Dermnet Skin Disease Atlas are to be used only as a reference. Dermnet does not provide medical advice, diagnosis or treatment. Use of images for any purpose including but not limited to research, commercial, personal, or non-commercial use is prohibited without prior.

Nov 2014: Sweet's Syndrome UK becomes an organization member of the charity Skin Conditions Campaign Scotland and SS patient representative for Scotland. This gives Sweet's Syndrome UK a greater ability to help those with SS, and spread awareness of SS in Scotland and across the UK. Feb 28th 2015: Sweet's Syndrome UK supports Rare Disease. Sweet's syndrome (SS) can be triggered by inflammatory bowel disease (IBD - Crohn's disease and ulcerative colitis). When this happens, SS normally develops in response to an IBD flare, but in up to 25% of cases, it appears before the diagnosis of IBD. This is a case of a 29-year-old man with CROHN'S disease (CD) involving the ascending colon Skin signs and systemic disease. Authoritative facts from DermNet New Zealand

Today is SWEET'S SYNDROME UK DAY, and I thought it would be relevant to post about Sweet's syndrome (SS) developing secondary to COVID-19. Infection, particularly upper respiratory tract and gastrointestinal, is a well documented trigger for SS Neutrophilic urticarial dermatosis (NUD) is a rare form of dermatosis. In clinical terms, it consists of a chronic or recurrent eruption comprising slightly elevated, pink to reddish plaques or macules. The elementary lesion lasts 24 to 48hours and resolves without leaving any residual pigmentation. Colchicine, doxycycline, and anakinra (2017 study by Grayson et al) can help to treat mouth ulcers in patients with the neutrophilic dermatosis, Behcet's syndrome, but may also be useful in those with Sweet's syndrome. Michelle (Administrator) Sweet's syndrome — also known as acute febrile neutrophilic dermatosis — is a rare skin condition marked by Acute febrile neutrophilic dermatosis. Sweet syndrome Sweet syndrome. Acute neutrophilic dermatosis. Authoritative facts about the skin from DermNet New Zealand.. Sweet syndrome (acute febrile neutrophilic dermatosis) is a rare skin condition, characterised by fever and sudden onset of painful skin lesions that appear mostly on the limbs and neck. 1,2 Mucosal surfaces such as the eyes and mouth may also be involved. 2. Sweet syndrome belongs to a heterogenic group of neutrophilic dermatoses 3, with.

Image Filename: sweets-syndrome-2.jpg Dermnet.com and the Dermnet Skin Disease Atlas are to be used only as a reference. Dermnet does not provide medical advice, diagnosis or treatment. Use of images for any purpose including but not limited to research, commercial, personal, or non-commercial use is prohibited without prior written consent.. Sweet syndrome is a rare skin disorder characterized by fever, inflammation of the joints (arthritis), and the sudden onset of a rash. The rash consists of bluish-red, tender papules that usually occur on the arms, legs, face or neck, most often on one side of the body (asymmetric). In approximately 80 percent of cases, Sweet syndrome occurs by. [CASE-STUDY] Sweet Syndrome in an Elderly Man With Well-Controlled Human Immunodeficiency Virus. This is a case of a 71-year-old male living with well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy, who developed skin lesions (almost-necrotic appearing papules) on both palms of his hands, and an altered mental status Sweet syndrome can go away by itself without treatment if it's not caused by another health condition. But this could take weeks or months. Corticosteroid pills can help with redness, itching. Sweet syndrome (or acute febrile neutrophilic dermatosis) is an autoinflammatory condition that is idiopathic in the majority of patients but can occur in association with malignancy or be drug induced. The rash of Sweet syndrome can vary but typically involves the sudden onset of tender papules and vesicles and some larger plaques or nodules

Sweet'S Syndrome (Acute Febrile Neutrophilic Dermatosis

such as Sweets syndrome for example. Second, the term fibrinoid necrosis, although frequently used, has no clearly defined meaning. Does it mean collagen destruction and cellular death, or does it refer to the accumulation of fibrin and fibrin products, or all of the above? Is it possible that in different situations the same name refer DermNet NZ. Genetic and Rare Diseases Information Center (GARD). HealthUnlocked. National ABOUT. Sweet's Syndrome UK is a Cardiff-based group that helps those with the rare autoinflammatory condition and neutrophilic dermatosis, Sweet's syndrome

Sweet's syndrome (acute febrile neutrophilic dermatosis

  1. or damage to the skin
  2. The Red scrotum syndrome (RSS) is a chronic condition characterised by persistent scrotal erythema associated with itching and/or a burning sensation and hyperalgesia. It always involves the anterior half of the scrotum, and may extend to its posterior part, and even to the base of the penis
  3. Definition / general. Noninfectious neutrophilic dermatosis with painful nodules / pustules that progress to necrotic ulcers with a characteristic violaceous edge. Pyoderma gangrenosum is a diagnosis of exclusion based on clinical and histological findings
  4. Image Filename: sweets-syndrome-4.jpg Dermnet.com and the Dermnet Skin Disease Atlas are to be used only as a reference. Dermnet does not provide medical advice, diagnosis or treatment. Use of images for any purpose including but not limited to research, commercial, personal, or non-commercial use is prohibited without prior written consent..
  5. Behcet's (beh-CHETS) disease, also called Behcet's syndrome, is a rare disorder that causes blood vessel inflammation throughout your body. The disease can lead to numerous signs and symptoms that can seem unrelated at first. They can include mouth sores, eye inflammation, skin rashes and lesions, and genital sores
  6. Sweet syndrome (i.e., acute febrile neutrophilic dermatosis) Red, tender papules that evolve into painful erythematous plaques and annular lesions on upper extremities, head, neck, backs of hands.

Wells syndrome is a rare eosinophilic disorder that primarily affects the skin. Affected people typically develop a skin rash that is often preceded by itching or burning skin. The rash consists of raised, red, swollen areas that may be warm to the touch. The symptoms generally come on rapidly and may last four to eight weeks Pyoderma gangrenosum is a rare, inflammatory skin disease where painful pustules or nodules become ulcers that progressively grow. Pyoderma gangrenosum is not infectious. Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab.. The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population Wilson DM, John GR, Callen JP. Peripheral ulcerative keratitis--an extracutaneous neutrophilic disorder:report of a patient with rheumatoid arthritis, pustular vasculitis,pyoderma gangrenosum, and Sweet''s syndrome with an excellent response tocyclosporine therapy. J Am Acad Dermatol. 1999 Feb. 40(2 Pt 2):331-4. . Daniels NH, Callen JP

Mast cell activation syndrome (MCAS) causes a person to have repeated severe allergy symptoms affecting several body systems. In MCAS, mast cells mistakenly release too many chemical agents, resulting in symptoms in the skin, gastrointestinal tract, heart, respiratory, and neurologic systems. Mast cells are present throughout most of our bodies and secrete different chemicals during allergic. Oral allergy syndrome (OAS) is an allergic condition which causes itching and swelling of the lips and mouth after eating raw fruit, vegetables or certain nuts. All raw foods that cause symptoms should be avoided Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease of normal but overactive histiocytes and lymphocytes that commonly appears in infancy, although it has been seen in all age groups. Fever, hepatosplenomegaly, pancytopenia, lymphadenopathy, and rash often comprise the initial presentation

Sweet's syndrome - Symptoms and causes - Mayo Clini

Cogan syndrome is a rare autoimmune disease that affects the eyes and inner ears. Symptoms of the syndrome include irritation and pain in the eyes, decreased vision, hearing loss, and vertigo.Other symptoms may include joint or muscle pain or inflammation of the blood vessels Adenosine Deaminase 2 deficiency (ADA2 deficiency) causes swelling of the blood vessels (vasculitis), leading to decreased blood flow affecting the organs and skin. Though the severity and age of onset can vary, most people with ADA2 deficiency begin having symptoms in childhood Autoinflammatory vs. autoimmune: The periodic fever syndromes fall into the autoinflammatory disease category. These conditions include familial Mediterranean Fever (FMF), cryopyrin associated periodic syndrome (CAPS), HIDS, Behcet's disease, systemic juvenile idiopathic arthritis (SIJA), and several other chronic diseases that have recurring fevers and inflammation as the main symptoms A rare entity called Vogt-Koyanagi syndrome occurs in some children following a viral illness. In an attempt to fight the virus, the body makes antibodies that, unfortunately, also attack the melanocytes. So, Debbie, it is possible that your son has a vitamin deficiency. It is also possible that the gray hairs are a visible sign of an important.

Malar rash, colloquially known as the butterfly rash, is an acute manifestation of SLE, present in 46-65% of patients (Vilá et al., 2004).The rash is characterized by a symmetrical fixed erythematous maculopapular lesion with slight scale occurring over both cheeks and nose, sparing the nasolabial folds (Figs 3.11, 3.12).The rash is typically transient, lasting from days to weeks. Grover's disease is a rare, itchy skin condition that most often appears in middle-aged men. WebMD explains the causes, symptoms, and treatment of this sudden rash

Sweet's syndrome (syn

  1. Connective tissue disease such as Ehlers-Danlos syndrome or lupus. Alcohol misuse. Cancer. HIV and other infections. Symptoms. Ecchymosis turns the skin a dark purple color. As the bruise heals.
  2. g cells in the bone marrow become abnormal. This leads to low numbers of one or more types of blood cells. MDS is considered a type of cancer
  3. start/discuss [edit source]. looks great!--Ozzie10aaaa 22:30, 14 March 2021 (UTC) . Welcome. Still a lot to do. Hopefully much of it can be done by bot. Doc James (talk · contribs · email) 22:43, 14 March 2021 (UTC) Im very ready to contribute(now that my modem is working)--Ozzie10aaaa 01:29, 18 March 2021 (UTC) email response Doc James--Ozzie10aaaa 20:36, 31 March 2021 (UTC
  4. What does Sweet's syndrome of the skin look like? The most common skin changes in Sweet's syndrome are raised red, pink or purplish tender skin lumps. These can be small (known as papules, which can be about 5-10 mm) or larger (known as nodules) and can join together to form bigger areas (known as plaques)
  5. Background: Sweet's syndrome (SS, acute neutrophilic dermatosis), most commonly presents as painful nodules and plaques on the skin and is usually accompanied by fever, leucocytosis. Neutrophilic dermatoses may be associated with malignancy, autoimmune diseases, pregnancy, infections, and medications
  6. Some people are born with the condition, others develop it later in life. Other known causes of anhidrosis include: Skin damage from burns, radiation therapy, or pore-clogging diseases such as psoriasis. Damage to the sweat glands from surgery, trauma or scar formation. Nerve damage caused by diabetes, alcoholism, and Guillain-Barre syndrome

Sweet Syndrome - NORD (National Organization for Rare

The most common for people with Crohn's disease are psoriasis, erythema nodosum, and pyoderma gangrenosum. Rarer skin issues associated with Crohn's include Sweet's syndrome and leukocytoclastic vasculitis, as well as mouth sores like aphthous ulcers (canker sores), angular cheilitis, and pyostomatitis vegetans The density of the infiltrate varied among cases. A biopsy specimen of 1 of the bullous lesions obtained from patient 3 revealed massive subepidermal edema, reminiscent of that seen in Sweet syndrome. Most of the lymphocytes stained with the T-lymphocyte markers Dapsone is a sulphonamide antibiotic. It is available only on prescription. It acts as an anti-inflammatory drug and has been used successfully as a treatment for several skin conditions such as dermatitis herpetiformis, pyoderma gangrenosum, Sweet's syndrome and vasculitis for many years

Wrap a firm compression bandage (ideally 1 inch, for example Coban, pictured) over the oedematous area, starting at penile tip. Leave bandage for 10-15 minutes (use a timer) Remove bandage and attempt to reduce foreskin over the glans. If unsuccessful, repeat bandage for further 15 minutes and re-attempt The American Academy of Dermatology was founded in 1938. It is the largest, most influential and representative dermatology group in the United States. With a membership of more than 19,000, it represents virtually all practicing dermatologists in the United States, as well as a growing number of international dermatologists. More Salicylate intolerance affects up to 0.6-2.5% of the general population, and about 10-20% of asthmatics 4, but is not as common as as gluten or lactose intolerance. The normal Western diet has 10-100 mg of naturally occurring salicylates going from fruits, vegetables, nuts, herbs and spices, jams, honey, tea, coffee, wines, and other plant. These patient information leaflets (PILs) are specially written by the BAD to help you understand more about a particular skin condition. They inform you what the condition is, what causes it, what can be done about it and where you can find out more information about it. Where possible, they advise you on what you [ sugar or sweet food; foods that are very spicy or acidic; Learn more about geographic tongue. Hairy tongue syndrome. Hairy tongue occurs when a certain type of cell on the tongue doesn't shed as.

Leukocytoclastic vasculitis (LCV) is a frequently-misused histopathologic term that describes the microscopic changes seen in various types of vasculitis affecting the skin and internal organs. However, LCV more typically refers to small-vessel vasculitis of the skin. The terms cutaneous LCV, cutaneous small-vessel vasculitis, and cutaneous. On average, each hot flash lasts for about three to four minutes. Hot flashes can occur for a few months to several years. In a few rare cases, some people had hot flashes for 10 years. Other signs of hormonal imbalance include: Constipation. Heavy or irregular periods, missed periods, frequent periods, or stopped periods

Herpes zoster oticus (Ramsay-Hunt syndrome) occurs with involvement of the vestibulocochlear nerve. Disseminated zoster , defined as > 20 vesicles outside of the primary and adjacent dermatomes, is chiefly a problem of immunocompromised patients (patients with HIV, patients with cancer, and those on immunosuppressive drugs) Skeeter syndrome is relatively rare, but having it means you're having an allergic reaction to a mosquito bite. You'll notice a bigger, longer-lasting mark if you get bit by a mosquito. The. Other skin disorders such as pemphigus vulgaris, bullous pemphigoid, lupus erythematosus, erythema multiforme and Sweets Syndrome. Basis for recommendation The information on the differential diagnosis of impetigo is based on Rooks textbook of dermatology [ Hay, 2016 ] and expert opinion in review articles [ Hartman-Adams, 2014 ; VanRavenstein.

Lactobacillus is a naturally occurring bacteria present within a woman's vagina. The overgrowth of these bacteria -- a condition called cytolytic vaginosis -- disrupts the normal vaginal environment, causing it to become more acidic 1 2.Symptoms of lactobacillus overgrowth mimic those experienced by women who have a vaginal yeast infection caused by the bacterium Candidas albicans Erythromelalgia is a rare disease- so much so it is called an orphan disease - leading to difficulty in diagnosis. A 2008 study by the Mayo Clinic estimated 1.3 people per 100,000 are affected by EM [2]. That means you are much more likely to be struck by lightning in your lifetime than be diagnosed with EM Posterior Reversible Encephalopathy Syndrome (PRES) PRES is a rare condition that affects the brain and can cause death. The cause of PRES is not known. If PRES is found early and treated, most people recover. Tell your doctor right away if you have any new or worsening medical problems including: headache, seizures, confusion, and vision problems A-Z Conditions. These patient information leaflets (PILs) are specially written by the BAD to help you understand more about a particular skin condition. They inform you what the condition is, what causes it, what can be done about it and where you can find out more information about it. Where possible, they advise you on what you can do.

Skeeter Syndrome is an allergy to mosquito saliva.It can present with extreme swelling, itching, blistering, infection, fever and in some cases anaphylactic shock, asthma and cellulitis. Most people will experience some level of allergic reaction, with itching and redness, individuals who suffer from skeeter syndrome experience a very extreme reaction Reticular erythematous mucinosis syndrome: review of the world literature and report of the syndrome in a prepubertal child. Pediatr Dermatol 1990; 7:1. Braddock SW, Kay HD, Maennle D, et al. Clinical and immunologic studies in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin Trimethylaminuria ('fish odour syndrome') Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It's also called fish odour syndrome. Sometimes it's caused by faulty genes that a person inherits from their parents, but this isn't always the case. There's currently no cure, but there are things that can help Burning tongue syndrome is a painful and often frustrating condition — some people compare it to having burned their mouth with hot coffee. The burning sensation often affects the tongue, the roof of the mouth, the gums, the inside of the cheeks, and the back of the mouth or throat. This condition can also be known as burning mouth syndrome, scalded mouth syndrome, glossodynia and. Yellow nail syndrome is a rare condition that can cause one or more nails to fall out. According to DermNet, the toenails may appear thick, yellowish, and appear to stop growing. Some topical vitamin E solutions have helped restore nail health. 13 . Natural Treatment options for Toenail Falling Of

Extracutaneous Sweet syndrome involving the

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 2 Aug 2021), Cerner Multum™ (updated 3 Aug 2021), ASHP (updated 30 July 2021. Erythema multiforme is a skin immune reaction that an infection or medication can trigger. Its name combines the Latin erythema (redness), multi (many), and forme (shapes) and. BOTOX ® is injected into the skin to treat the symptoms of severe underarm sweating (severe primary axillary hyperhidrosis) when medicines used on the skin (topical) do not work well enough in people 18 years and older. It is not known whether BOTOX ® is safe or effective for severe sweating anywhere other than your armpits.. In a clinical study, the duration of response in patients. Palmoplantar psoriasis is a type of psoriasis that affects the palms of the hands and the soles of the feet. Psoriasis is an autoimmune condition that can flare up with exposure to certain triggers

Il s'agit d'une maladie de peau de description ancienne (1798), caractérisée par la présence de nouures (sorte de boules sous la peau mal délimitées) douloureuses, touchant les faces d'extension des jambes, plus rarement les cuisses et les avant-bras, évoluant sur 3 à 6 semaines en ne laissant aucune séquelle dermatologique Other forms of treatment for porokeratosis plantaris include the use of keratolytic agents such as salicylic acid whose goal is eat away at the lesion by macerating the area. This can be done alone or in conjunction with curettement in an effort to extend the period of relief. These lesions may also be injected diabetes sweets nails. Managing diabetes doesn't mean you need to sacrifice enjoying foods you crave. Diabetes Self-Management offers over 900 diabetes friendly recipes to choose from including desserts, low-carb pasta dishes, savory main meals, grilled options and more..station-tabs.mod-full-width .station-tabs-link.is-active:aftermargin-top:3px;transform:rotate(-135deg).station-tabs. Leukocytoclastic vasculitis is also referred as hypersensitivity vasculitis or hypersensitivity angiitis.The disease is presented by small spots of discolorations known as purpura. The spot is caused by the bleeding beneath the skin which in turn causes the reddish or purplish discoloration of the skin

Erythema nodosum pathology | DermNet NZSystemic Disease and Skin Manifestations at MercerDoctor Education Archives - Page 6 of 17 - Infinity PathologyErysipelas pathology | DermNet NZ

The cause: Seb derm, as most derms call it, is one of the most common scalp conditions. Cradle cap in babies parlays into red, itchy patches with greasy scale or dandruff in an adult. It isn't. It can cause asthma symptoms of wheezing, chest tightness and difficulty breathing. Symptoms begin within minutes after exposure to latex containing products. The most severe latex allergy can result in anaphylaxis, a serious allergic reaction involving severe breathing difficulty and/or fall in blood pressure (shock) Shingles - symptoms, treatment, vaccination. Shingles is a viral infection, the first symptom of which is usually a tingling, sharp, burning pain under the skin. This is followed 1 - 14 days later by a red rash and blisters. Early treatment can help to shorten the duration of infection and reduce the risk of complications Seborrhoeic keratoses (SK) are also known as seborrhoeic warts, and as basal cell papillomas. They are benign growths due to a build-up of skin cells. SK are very common, harmless, often pigmented, growths on the skin. In the UK more than half the men and more than third of women would have at least one SK A sun allergy is an immune system reaction to sunlight, most often, an itchy red rash. The most common locations include the V of the neck, the back of the hands, the outside surface of the arms and the lower legs. In rare cases, the skin reaction may be more severe, producing hives or small blisters that may even spread to skin in clothed areas Sjogren's syndrome - is a common autoimmune disease that mainly affects the eyes and salivary glands, but can also affect the sweat glands. Salivary duct blockages - for example, tiny stones made from saliva minerals may lodge in the salivary ducts and restrict saliva flow